Women's health has been misunderstood—and often ignored—for decades.

In this episode, Dr. Pamela Peeke joins Buck Joffrey and Nikki Leigh to set the record straight. From the outdated belief that “women are just small men” to the shocking truth about flawed medical research, Dr. Peeke reveals what every woman needs to know about body composition, hormone therapy, emotional eating, and chronic stress. Her “Mind, Mouth, and Muscle” approach offers a powerful framework for lasting change.

Dr. Ryan Rosner went from the NFL to the lab—now he's advancing some of the most promising developments in aging science. In this episode, we talk about his transition into molecular aging research and the science behind hypoxia, plasmid therapy, and follistatin’s role in muscle and metabolic health.

We cover key topics including cellular resilience, epigenetic rejuvenation, gene therapy, and emerging applications of plasmid technology. Rosner also shares insights into ongoing clinical trials, hibernation research, and how muscle tissue may be central to extending health span.

What do you do when your husband cheats on you… while you’re battling cervical cancer?

Would you trust a babysitter who gave your toddler melatonin without asking?

And how far is too far when it comes to dietary boundaries?

In this episode of Longevity Junky, Nikki Leigh and Dr. Buck Joffrey unpack Reddit stories that expose the messy, complicated realities of health in everyday life.

From HPV-related cancer and kidney infections to parenting fails and nutrition drama, they break down the health facts behind each story, unpacking symptoms, consequences, and what people got right (or totally wrong).

What if you could slow aging, repair cells, and boost your brain—all by breathing oxygen under pressure?

Dr. Shai Efrati joins Longevity Junky to unpack the science and protocols behind hyperbaric oxygen therapy (HBOT). This isn’t just oxygen—it’s precision medicine. We dive deep into how HBOT enhances oxygen delivery to tissues, triggers cellular repair, and may even lengthen telomeres.

From cognitive enhancement to VO2 max gains in athletes, HBOT’s potential spans performance, recovery, and aging. Learn how the hyperoxic-hypoxic paradox works, why metabolic health matters, and how treatment protocols are fine-tuned through clinical evaluation. We also discuss real risks, side effects, cost, and the importance of doing HBOT in a medical-grade facility.

What if you could trigger the benefits of a 36-hour fast—without skipping a single meal? Dr. Chris Rhodes, nutritional biochemist and founder of Mimio, joins Nikki and Buck to unpack the science behind fasting mimetics. Discover how specific molecules can mimic the effects of prolonged fasting, from activating autophagy to improving insulin sensitivity, reducing inflammation, and suppressing appetite. Plus, we dives into weird wellness history with Lord Byron's vinegar obsession and how apple cider vinegar actually affects metabolism.

Dr. Sharon Bergquist—Harvard-trained physician, Emory researcher, and author of The Stress Paradox—joins Longevity Junky to flip the script on everything we thought we knew about stress. Discover how good stress (yes, it exists!) can supercharge your cellular health, build resilience, and even slow down biological aging. From cold exposure and intermittent fasting to emotional challenges that light you up, this episode explores the science of hormesis and the “Goldilocks zone” of stress for optimal longevity.

Can Alzheimer’s be reversed without drugs?

Dr. Dean Ornish says yes—and he has the clinical data to prove it. In this episode of Longevity Junky, Nikki and Buck sit down with the father of lifestyle medicine to explore a groundbreaking study showing how diet, exercise, stress reduction, and community can actually stop—or even reverse—early-stage Alzheimer’s. From the science of neuroplasticity to the power of social support, this conversation is packed with insight, hope, and practical steps anyone can take.

Get ready for some of the wildest, most jaw-dropping medical stories ever shared on Reddit. From ER scammers faking injuries for pain meds… to DIY tracheotomies, exploding intestines, and near-fatal sex injuries—these real-life cases are as unbelievable as they are horrifying.

Join Dr. Buck Joffrey and Nikki Leigh as they break down these totally unhinged Reddit stories with useful medical insights and some humor along the way.

What if preserving your body after death wasn’t science fiction—but science in progress?

In this mind-expanding conversation, James Arrowood of Alcor dives deep into the science and ethics of cryonics, explaining how ultra-cold preservation of human tissue could transform the future of medicine, organ banking, and even space travel. Learn how cryonics works, how Alcor operates as a non-profit, and what it means for our understanding of consciousness, trauma medicine, and longevity.

We explore the cutting-edge technology behind cryopreservation, why some scientists believe revival may be possible, and how preserving the brain could one day unlock new frontiers in medical research. Whether you're a skeptic or a believer, this episode will challenge how you think about life, death, and everything in between.

Discover how AI is revolutionizing personalized nutrition, diet tracking, and longevity in this episode of Longevity Junky. Caltech-trained physicist and AI entrepreneur Dr. Dmitriy Richard Starson reveals the tech behind his groundbreaking platform that analyzes your meals through photos and voice—no more tedious logging. Learn how AI can tailor your food choices, improve metabolic health, and even help doctors deliver better care.

Is boredom slowly killing you? Cognitive neuroscientist Dr. James Danckert joins Longevity Junky to break down the science of boredom—what it does to your brain, how it’s linked to depression, addiction, even heart disease, and why your response to boredom could affect your longevity. Plus, why some people shock themselves out of boredom (literally).

Did you know microplastics could be silently damaging your hormones, fertility, and heart health? In this explosive episode, Dr. Leonardo Trasande—NYU professor, bestselling author, and global leader in environmental pediatrics—joins Buck and Nikki to reveal how these invisible plastic particles are infiltrating our bodies through food, water, and even air. Learn how microplastics disrupt your endocrine system, spike inflammation, and accelerate aging—and what you can actually do to reduce your exposure. Don’t miss this eye-opening conversation on the hidden health threat of our time.

What supplements do two longevity junkies actually take? In this episode, Dr. Buck Joffrey and Nikki Leigh reveal their personal daily supplement stacks—the real-life regimens they follow to stay sharp, healthy, and (hopefully) young forever.

But here’s the kicker… not all supplements on store shelves are what they seem. Buck shares the shocking results of a study revealing that nearly half of herbal supplements don’t even contain what they claim. Nikki and Buck break down how to cut through the BS, which brands they trust, and why they only take what they know works.

What if rethinking relationships could unlock deeper connection, emotional well-being, and even longevity? In this episode of Longevity Junky, Nikki and Buck sit down with Dr. Joli Hamilton—research psychologist, certified sex educator, and relationship coach—to explore the world of consensual non-monogamy, jealousy, and alternative relationship dynamics.

Dr. Joli shares her personal journey from monogamy to a cohabiting triad, the emotional complexities of jealousy, and how embracing unconventional relationship structures can support mental and emotional health. Whether you’re curious about polyamory, navigating jealousy, or seeking deeper intimacy, this conversation breaks down the myths and highlights the transformative power of self-awareness and communication.

Oscar-winning screenwriter and five-time world champion triathlete—Lesley Paterson doesn’t just break barriers; she obliterates them. From pushing through brutal endurance races to fighting for All Quiet on the Western Front, her mindset is an absolute masterclass in resilience. We dive into her elite fitness strategies, how she overcame chronic Lyme disease, and the shocking connection between metabolic health and cancer.

In this episode of Longevity Junky, Buck Joffrey and Nikki Leigh sit down with David Mark Dror, author of Investors in Longevity, to explore the multi-billion-dollar investments driving longevity breakthroughs. Discover how Jeff Bezos, Peter Thiel, and major biotech firms are funding research in:

- Gene therapy and cellular reprogramming to slow aging

- AI-driven drug discovery for life extension

- Regenerative medicine and stem cell therapy

Plus, we answer a listener’s burning question: What essential lab tests should you get for optimal health—ones most doctors don’t order?

If you're curious about how the biggest names in tech and biotech are investing in longevity—and what it means for the future of healthcare, wealth, and aging—this episode is a must-listen!

How do you maximize muscle growth? What’s the optimal way to train for hypertrophy? Dr. Mike Israetel, fitness and performance expert, joins Buck Joffrey and Nikki Leigh to break down the science of building muscle—from protein timing to training volume and even future muscle-enhancing drugs. Plus, insights on sleep, recovery, and how genetics impact gains.

Buck and Prof Glen Jeffery dive deep into the science of red light therapy, revealing how it boosts mitochondrial function and potentially slows aging. He shares groundbreaking insights from clinical trials, showing how red light can recharge cellular energy and improve vision health. We get into practical tips on using red light therapy—where to get it, when to use it, and what to watch out for in devices.

Learn more about Prof Jeffery:

https://profiles.ucl.ac.uk/7465-glen-jeffery

Bioxcellerator is offering our listeners special discounts and offers on stem cell therapy. If you are interested, please reach out to Liz at longevityjunky@bioxcellerator.com.

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What happens when a UFC champion turns his focus from fighting in the cage to fighting aging? Former two-time UFC bantamweight champion TJ Dillashaw joins Nikki and Buck for a deep dive into stem cell therapy, peak performance, and biohacking longevity. TJ shares his experience with BioAccelerator’s advanced stem cell treatments, how they’ve impacted his injuries, and why he’s all-in on cutting-edge health optimization. From nutrition, fasting, and sleep hacks to training smarter—not just harder—this episode is packed with actionable longevity insights from an elite athlete who’s always pushing the limits.